Peran Nutraseutikal sebagai Terapi Pendukung dalam Pengelolaan Gejala Asma: Tinjauan Literatur

Syamsuri Syakri, Khaerani Khaerani, Karlina Amir Tahir, Indah Indah

Sari


Di era modern ini, asma tetap menjadi penyakit pernapasan kronis yang signifikan yang mempengaruhi jutaan orang di seluruh dunia, dengan keterbatasan dalam terapi farmakologis saat ini akibat efek samping danpenurunan kepatuhan. Tinjauan literatur ini bertujuan untuk mengeksplorasi peran nutraseutikal berbasis tumbuhan sebagai terapi tambahan untuk pengelolaan gejala asma dengan menganalisis studi eksperimentalterbaru. Ulasan ini dilakukan menggunakan artikel penelitian asli yang diterbitkan antara tahun 2019 dan 2025,yang bersumber dari PubMed, ScienceDirect, ResearchGate, Google Scholar, dan Publish or Perish. Kriteria inklusi berfokus pada studi yang menyelidiki aktivitas farmakologis tanaman obat terkait asma menggunakan model in vitro, in vivo, dan in silico. Sebanyak 23 spesies tumbuhan dari berbagai famili telah dianalisis, termasuk Matricaria chamomilla, Datura stramonium, Atropa belladonna, Polygala spp., Carapichea ipecacuanha, Mimosa pudica, dan anggota famili Asteraceae. Temuan menunjukkan bahwa tanaman- tanaman ini memiliki mekanisme multi-target yang relevan dengan pengurangan gejala asma, termasuk efek anti-inflamasi, antioksidan, imunomodulator, bronkodilator, mukolitik, dan pelindung epitel. Senyawa bioaktif utama seperti flavonoid, alkaloid, saponin, polifenol, terpenoid, dan siklotida diidentifikasi sebagai kontributor efek-efek ini melalui jalur molekuler seperti NF-?B, MAPK, JAK/STAT, PI3K/AKT, dan TLRs. Meskipun sebagian besar bukti berasal dari model praklinis, konsistensi hasil biologis menunjukkan potensi kuat untuk penerapan klinis. Studi lebih lanjut diperlukan untuk menstandarkan ekstrak, memvalidasi profil keamanan, dan melakukan uji klinis pada manusia untuk mengintegrasikan nutraseutikal ini ke dalam manajemen asma berbasis bukti.

KATA KUNCI: Asma, nutraseutikal, tanaman obat


Teks Lengkap:

PDF

Referensi


Abedi, H., Karimi, M., Sadeghi, N., Jahromi, H. K., Jahromi, M., Ranjbar, A., . . . Dialameh, S. (2023). The Positive Effect of Atropa belladonna on Inflammatory Cytokines in the Animal Model of Multiple Sclerosis. International Clinical Neuroscience Journal, 10, 1-10. doi:10.34172/icnj.2023.10

Antoniak, K., Sroka, E. S., Szymanski, M., Makuch, M. D., Piontek, J. C., & Katarzyna, K. (2023). Antiangiogenic, Anti-Inflammatory and Antioxidant Properties of Bidens tripartite Herb, Galium verum Herb and Rumex hydrolapathum Root. Molecules, 1-16. doi:10.3390/molecules28134966

Azman, S., Sekar, M., Bonam, S. R., Gan, S. H., Wahidin, S., Lum, P. T., & Dhadde,

S. B. (2021). Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review. Journal of Asthma and Allergy, 641-662. doi:10.2147/JAA.S296391

Babayeva, M., Tabynov, K., Nurpeisov, T., Fomin, G., Renukaradhya, G. J., Petrovsky, N., & Tabynov, K. (2022). A recombinant Artemisia vulgaris pollen adjuvanted Art v 1 protein-based vaccine treats allergic rhinitis and bronchial asthma using pre- and co seasonal ultrashort immunotherapy regimens in sensitized mice. Frontiers In Immunology, 1-14.

doi:10.3389/fimmu.2022.983621

Baydar, R., Karadag, A. E., Biltekin, S. N., Gulzemeric, E., & Demirci, F. (2024). In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide. Acta Pharmaceutica Sciencia, 62(1), 183-192.

doi:10.23893/1307-2080.APS6212

Bisht, D., Kumar, D., Kumar, D., Dua, K., & Chellappan, D. K. (2021). Phytochemistry and pharmacological activity of the genus artemisia. Arch. Pharm. Res, 44, 439-474. doi:10.1007/s12272-021-01328-4

Chaudari, P. H. (2023). Pharmacognostical and phytochemical studies on leaves of Tagetes erecta Linn. Ayurveda and Integrated Medical Sciences, 8(7), 37. doi:10.21760/jaims.8.7.5

Chen, T., Zhou, X., Zhu, M., Chen, X., Chang, D., Lin, Y., . . . Huang, M. (2024). Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation. Journal of Ethnopharmacology, 1-15. doi:10.1016/j.jep.2024.118418

Damergi, B., Essid, R., Fares, N., Khadraoui, N., Ageitos, L., Alaya, A. B., . . . Tabbene, O. (2023). Datura stramonium Flowers as a Potential Natural Resource of Bioactive Molecules: Identification of Anti-Inflammatory Agents and Molecular Docking Analysis. Molecules, 1-21. doi:10.3390/molecules28135195

Das, J., & Sarkar, B. R. (2023). Ethnomedicinal and Pharmacological Importance of Atropa Belladonna: A Review. International Journal of Pharmacognosy, 10(8), 448-453. doi:10.13040/IJPSR.0975-8232.IJP.10(8).448-53

Dayel, F. F., Rehman, N. U., Salkini, M. A., Al Dosari, A. F., & Saeedan, A. S. (2024). Effect of Drying on the Quantity and Composition of Artemisia monosperma Essential Oil and Exploring the Bronchodilator Effect Using Guinea Pig Tracheal Muscles. ACG Publication, 18(4), 468-473.

doi:10.25135/rnp.470.2405.3233

Dipiro, J. T., Yee, G. C., Haines, S. T., Nolin, T. D., Ellingrod, L. V., & Posey, L. M. (2023). Pharmacotherapy: A Pathophysiologic Approach (12th ed.). New York: Mc Graw Hill.

Drif, A. I., Yucer, R., Damiescu, R., Ali, N. T., Hagar, T. H., Avula, B., Efferth,

T. (2024). Anti-Inflammatory and Cancer-Preventive Potential of Chamomile (Matricaria chamomilla L.): A Comprehensive In Silico and In Vitro Study. Biomedicines, 1-35. doi:doi.org/10.3390/biomedicines12071484

Epure, A., Pârvu, A. E., Vlase, L., Benedec, D., Hanganu, D., Ovidiu, O., Oniga,

L. (2023). New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture. Pharmaceuticals, 1-15.

doi:10.3390/ph16030358

Falanga, C. M., Steinborn, C., Muratspahic, E., Marisa, A., Klemd, Z., Winker, M., . . . Grundemann, C. (2022). Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro. Europe PMC Funders Group, 1-23. doi:10.1016/j.biopha.2022.113120

Fateen, N., Ramasubramanian, A., & Ramani, P. (2025). Preliminary Evaluation of the Antimicrobial, Anti-Inflammatory, Antioxidant, and Cytotoxic Activities of Taraxacum officinale Leaf Extract: An in vitro Study. Pharmacogn. Res, 17(1), 277-282. doi:10.5530/pres.20252021

Hlel, T. B., Borges, T., Rueda, A., Smaali, I., Marzouki, M. N., & Seiquer, I. (2019). Polyphenols bioaccessibility and bioavailability assessment in ipecac infusion using a combined assay of simulated in vitro digestion and Caco-2 cell model. International Journal of Food Science and Technology, 1566-1575.

doi:10.1111/ijfs.14023

Joshua, P. E., Yahaha, J., Ekpo, D. E., Ogidigo, J. O., Odiba, A. S., Asomadu, R. O., . . . Adeniyi, O. S. (2022). Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide induced immunosuppression in Wistar rats. BMC Immunology, 1-19. doi:10.1186/s12865-022-00519-y

Kakurde, S. B., & Reshi, N. A. (2023). A Review on Mimosa pudica Linn. (Sensitive Plant) Ethnomedicinal and Pharmacological studies. International Journal of Research in Pharmacy and Allied Science (IJRPAS), 2(5), 49-55. Retrieved from https://www.researchgate.net/publication/379732375

Karima, M. (2024). Ethnobotanical Research on Medicinal Plants Used for Respiratory Diseases: Results of a Survey in Fez, Morocco. TRADITIONAL AND INTEGRATIVE MEDICINE, 10(1), 48-58.

doi:10.18502/tim.v10i1.18223

Kato-Noguchi, H., & Kurniadie, D. (2024). The Invasive Mechanisms of the Noxious Alien Plant Species Bidens Pilosa. Plants, 13, 1-18. doi:10.3390/plants13030356 Khatib, S., Sobeh, M., Faraloni, C., & Bouissane, L. (2023). Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence. Frontiers in Pharmacology, 1-46.

doi:10.3389/fphar.2023.1169629

Kristianingsih, A., Soetrisno, Reviono, R., & Wasita, B. (2024). Molecular Docking Study of Quercetin from Ethanol Extract of Mimosa pudica Linn on Asthma Biomarkers. Tropical Journal of Natural Product Research, 8(10), 8640-8645. doi:10.26538/tjnpr/v8i10.4

Kristianingsih, A., Soetrisno, Reviono, Wasita, B., Widyaningsih, V., & Cilmiatry, R. (2024). Effects of Mimosa pudica Extract on Asthma Biomarkers and Fetal Development in Pregnant Rats. Tropical Journal of Natural Product Research, 8(10), 8796-88002. doi:10.26538/tjnpr/v8i10.23

Kusmiati, K., Afiati, F., Widhiani, C., Aditia, A., Elviani, D. D., & Kanti, A. (2021). The Potential of Lutein Extract of Tagetes erecta L. Flower as an Antioxidant and Enhancing Phagocytic Activity of Macrophage Cells. Intech Open, 1-15. doi:10.5772/intechopen.95965

Li, Q., Abdulla, R., Xin, X., Guipeng, X., Xiaolong, K., Feicui, Z., & Asia, H. A. (2023). Profiling of chemical constituents of Matricarla chamomilla L. by UHPLC-Q-Orbitrap-HRMS and in vivo evaluation its anti-asthmatic activity. Heliyon, 1-14. doi:10.1016/j.heliyon. 2023.e15470

Loucif, K., Mebarki, R., Youmbai, Nedjimi, M. S., Belabed, H. N., Zatla, I., Amira,

S. (2023). Antioxidant, Analgesic, and Anti-Inflammatory Effect of Matricaria Chammomilla Aqueous Extract. Tobacco Regulatory Science, 9(1), 3159-3172. doi:10.18001/TRS.9.1.221

Lyu, Y. R., Lee, S. W., Kim, S. Y., Han, H. B., Yang, W. K., Kim, S. H., Park, Y.

C. (2022). Herbal Medicines for the Treatment of Chronic Obstructive Airway Diseases (Asthma or Chronic Obstructive Pulmonary Disease): A Prospective Observational Study. Hindawi, 1-12. doi:10.1155/2022/3485757

Mihyaoui, A. E., Silva, J. C., Charfi, S., Castillo, M. E., Lamarti, A., & Arnao, M. B. (2022). Chamomile (Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses. Life, 1-41.

doi:10.3390/life12040479

Mischenko, O., Kyrychenko, I., Tetiana, G., Kalko, K., & Hordiei, K. (2022). RESEARCH ON THE PHENOLIC PROFILE, ANTIRADICAL AND ANTI- INFLAMMATORY ACTIVITY OF A THICK HYDROALCOHOLIC

FEVERFEW (Tanacetum parthenium L.) HERB EXTRACT. ScienceRise: Pharmaceutical Science, 5(39), 91-99. doi:10.15587/2519-4852.2022.266400

Mondal, S., & Moktan, S. (2020). A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review. Indian Journal of Pharmaceutical Education and Research, 54(2), 856-864. doi:10.5530/ijper.54.2s.61

Nagy, C. B., Banica, F., Tünde, J., Vicas, L. G., Marian, E., Muresan, M. E., . . . Pallag,

A. (2022). Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. Plants, 1-20. doi:10.3390/plants11091244

Nasir, B., Khan, A. U., Baig, M. W., Althobaiti, Y. S., Faheem, M., & Haq, I.-U. (2022). Datura stramonium Leaf Extract Exhibits Anti-inflammatory Activity in CCL4-Induced Hepatic Injury Model by Modulating Oxidative Stress Markers and iNOS/Nrf2 Expression. Hindawi, 1-20. doi:10.1155/2022/1382878

Osman, A., Ali, Z., Pandey, P., Zulfikar, F., Zhao, J., Bharathi, A., . . . Khan, I. (2025). Undescribed alkamides from Echinacea purpurea and Echinacea angustifolia: Chemical composition and anti-inflammatory activity. Chemistry and Biodiversity, 1-10. doi:10.1002/cbdv.202500407

Peng, J., Zhao, F., Kang, X., Aierken, N., & Li, Q. (2025). Matricaria chamomilla L. Ameliorates Asthma by Protecting OVA-Induced Bronchial Epithelial Cells Through Suppressing Autophagy and Apoptosis. Food Science & Nutrition, 1-

doi:10.1002/fsn3.70030

Schepetkin, I. A., Özek, G., Özek, T., Kirpotina, L. N., Khlebnikov, A. I., Klein, R. A., & Quinn, M. T. (2022). Neutrophil Immunomodulatory Activity of Farnesene, a Component of Artemisia dracunculus Essential Oils. Pharmaceuticals, 1-17. doi:10.3390/ph15050642

Sharma, M., Dhaliwal, I., Rana, K., Delta, A. K., & Kaushik, P. (2021). Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review. Antioxidants, 1-12. doi:10.3390/antiox10081291

Son, S.-R., Yoon, Y.-S., Hong, J.-P., Kim, J.-M., Lee, K.-T., & Jang, D.-S. (2022).

Chemical Constituents of the Roots of Polygala tenuifolia and Chemical Constituents of the Roots of Polygala tenuifolia and. Plants, 1-14. doi:10.3390/plants11233307

Sudeep, H. V., Gouthamchandra, K., Ramaniah, I., Raj, A., Naveen, P., & Shyramprasad, K. (2023). A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice. Pharmaceutical Biology, 61(1), 1211-1221.

doi:10.1080/13880209.2023.2244000

Sulistanti, E., Pratama, I. S., Hidayanti, A. R., & Wirasisya, D. G. (2022). IN VITRO TEST OF MUCOLITICAL ACTIVITY OF DECOCTION OF HERBA PUTRI

MALU (Mimosa pudica L). Jurnal Medika Udayana, 11(7), 56-60.

doi:10.24843.MU.2022.V11.i7.P10

Thomas, D., McDonald, V. M., Pavord, I. D., & Peter, G. G. (2022, September). Asthma remission: what is it and how can it be achieved? EUROPEAN RESPIRATORY JOURNAL, 60, 1-15. doi:10.1183/13993003.02583-2021

Vieira, S. F., Gonçalves, V. M., Llaguno, C. P., Macías, F., Tiritan, M. E., Reis, R.

L., . . . Neves, N. M. (2022). On the Bioactivity of Echinacea purpurea Extracts to Modulate the Production of Inflammatory Mediators. International Journal of Molecular Sciences, 23, 1-25. doi:10.3390/ijms232113616

Vijayalakshmi, M., Dhanapradeeba, V., Kunjiappan, Sundar, K., & Pandian, S. R. (2023). Targeting TLRs with the Derivatives of Mimosa Pudica: An In Silico Approach. Biointerface Research in Applied Chemistry, 13(3), 1-11. doi:10.33263/BRIAC133.237

Wennergren, G., Liendberg, A., Kauppi, P., Kankaanranta, H., Langhammer, A., & Backman, H. (2025). Glimpses of diagnostic tools and treatment of asthma in Sweden, Norway, and Finland from a medico-historical perspective. Respiratory Medicine, 1-10. doi:10.1016/j.rmed.2025.108139

Wu, Y., Fu, H., Yang, X., Leng, F., Huang, Y., Deng, H., . . . Zhang, S. (2021). Polygalaxanthone III downregulates inflammation in the lipopolysaccharide- stimulated RAW264.7 macrophages: A quantibody array analysis. Journal of Pharmacological Sciences, 184-191. doi:10.1016/j.jphs.2021.06.010

Xin, Y. J., Choi, S., Roh, K. B., Cho, E., Ji, H., Weon, J. B., . . . Jung, E. (2021). Anti-

Inflammatory Activity and Mechanism of Isookanin, Isolated by Bioassay- Guided Fractionation from Bidens pilosa L. Molecules, 1-14. doi:10.3390/molecules26020255

Yan, Q., Xing, Q., Liu, Z., Zou, Y., Liu, X., & Xia, H. (2024). The phytochemical and pharmacological profile of dandelion. Biomedicine & Pharmacotherapy, 1-17. doi:10.1016/j.biopha.2024.117334

Zhao, Y., Huang, H., Zou, H., Oian, Y., Wang, X., Guan, W., . . . Chai, R. (2025). Effects of Artemisia annua-Sublingual Immunotherapy on Asthma Control and Pulmonary Function in Patients with Mild-Moderate Allergic Asthma. International Archives of Allergy and Immunology, 1-14. doi:10.1159/000543864




DOI: https://doi.org/10.52161/jiphar.v13i1.905

Refbacks

  • Saat ini tidak ada refbacks.


View My Stats

Kantor Sekretariat:
SEKOLAH TINGGI KESEHATAN AL-FATAH BENGKULU
Mail  : Jln. Indragiri Gang 3 Serangkai,Padang Harapan, Kota Bengkulu, Kode Pos : 38224, Indonesia
Telepon : (0736)27508
Fax : (0736)27508
E-mail : jurnalilmiahpharmacy@gmail.com
 
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License
 
2019 STIKES Al Fatah